Reduced expression of Ia antigens by thymic epithelial cells of aged mice.
نویسندگان
چکیده
Thymic Ia antigen expression was examined with biochemical and immunohistochemical techniques. We found that expression of Ia antigens was reduced in thymic tissue of aged mice and that much of this loss was associated with cortical thymic epithelial cells. The ontologic pattern of Ia antigen expression in the thymus closely followed that observed for thymic weight, reaching maximal values at 4 wk of age and declining thereafter.
منابع مشابه
Mayrhofer and Schon - Hegrad 2099
Antigens of the Ia type are classically found on B lymphocytes (1), some activated T lymphocytes (2), and accessory cells of the macrophage/dendri t ic cell lineages (3, 4) in mice, and have a similar limited tissue distribution in the rat (5, 6, 7). They are antigenic determinants on surface glycoproteins that have important roles in antigen presentation to T lymphocytes, in cell interactions ...
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عنوان ژورنال:
- Journal of immunology
دوره 133 1 شماره
صفحات -
تاریخ انتشار 1984